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1034 matches
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organism
protein
1)
Escherichia coli K12
ytfE - Iron-sulfur cluster repair protein RIC; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions.
[a.k.a. AAC77166.1, b4209, NZ_STEB01000013.1,
Regulator of cell morphogenesis and NO signaling
]
2)
Homo sapiens
SCRIB - Protein scribble homolog; Scaffold protein involved in different aspects of polarized
cells
differentiation
regulating
epithelial and neuronal
morphogenesis
. Most probably functions in the establishment of apico-basal
cell
polarity. May function in
cell
proliferation
regulating
progression from G1 to S phase and as a positive
regulator
of apoptosis for instance during acinar
morphogenesis
of the mammary epithelium. May also function in
cell
migration and adhesion and hence
regulate
cell
invasion through MAPK
signaling
. May play a role in exocytosis and in the targeting synaptic vesicle [...]
[a.k.a. 6EEY, R-HSA-162582, ENST00000356994]
3)
Homo sapiens
PAK3 - Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different
signaling
pathways including cytoskeleton
regulation
,
cell
migration, or
cell
cycle
regulation
. Plays a role in dendrite spine
morphogenesis
as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...]
[a.k.a. AB102287, BAC80755.1, NM_001324329]
4)
Homo sapiens
RASIP1 - Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific
regulator
of GTPase
signaling
,
cell
architecture, and adhesion, which is essential for endothelial
cell
morphogenesis
and blood vessel tubulogenesis.
Regulates
the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA
signaling
and dampening ROCK and MYH9 activities in endothelial
cells
(By similarity). May act as effector for Golgi-bound HRAS and other Ras- like proteins. May promote HR [...]
[a.k.a. ENST00000599291.1, ENST00000594232, 54922]
5)
Homo sapiens
PROM1 - Prominin-1; May play a role in
cell
differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol- containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial
cells
. During early retinal development acts as a key
regulator
of disk
morphogenesis
. Involved in
regulation
of MAPK and Akt
signaling
pathways. In neuroblastoma
cells
suppresses
cell
differentiation such as neurite outgrowth in a RET-dependent manner.
[a.k.a. EAW92750.1, A0A0A0N0M1, XP_006714037]
6)
Homo sapiens
COMMD5 - COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively
regulates
cell
proliferation. Negatively
regulates
cell
cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent
signaling
pathway. Involved in kidney proximal tubule
morphogenesis
(By similarity). Down-
regulates
activation of NF-kappa-B.
[a.k.a. R-HSA-8951664, AK023070, COMMD5-206]
7)
Homo sapiens
PRKX - cAMP-dependent protein kinase catalytic subunit PRKX; Serine/threonine protein kinase
regulated
by and mediating cAMP
signaling
in
cells
. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial
morphogenesis
.
Regulates
myeloid
cell
differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial
cell
migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial
cell
proliferation, migration and vascular- like stru [...]
[a.k.a. R-HSA-388396, R-HSA-9006925, NP_005035]
8)
Homo sapiens
EPHB4 - Ephrin type-B receptor 4; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent
cells
, leading to contact-dependent bidirectional
signaling
into neighboring
cells
. The
signaling
pathway downstream of the receptor is referred to as forward
signaling
while the
signaling
pathway downstream of the ephrin ligand is referred to as reverse
signaling
. Together with its cognate ligand/functional ligand EFNB2 it is involved in the
regulation
of
cell
adhesion and migration, and plays a central role in heart
morphogenesis
, angiogenesis and bl [...]
[a.k.a. uc011kkg.2, ENST00000616502.4, EPHB4-209]
9)
Homo sapiens
VANGL2 - Vang-like protein 2; Involved in the control of early
morphogenesis
and patterning of both axial midline structures and the development of neural plate. Plays a role in the
regulation
of planar
cell
polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing
cells
in the outflow tract and seems to act via RHOA
signaling
to
regulate
this process. Required for
cell
surface localization of FZD3 and FZD6 in the inner ear (By similarity).
[a.k.a. R-HSA-162582, R-HSA-4608870, R-HSA-195721]
10)
Homo sapiens
SFRP4 - Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt
signaling
through direct interaction with Wnts. They have a role in
regulating
cell
growth and differentiation in specific
cell
types (By similarity). SFRP4 plays a role in bone
morphogenesis
. May also act as a
regulator
of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4
signaling
(By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
[a.k.a. NP_003005.2, Secreted frizzled related protein 4, AAH47684.1]
11)
Homo sapiens
CTNND2 - Catenin delta-2; Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the
regulation
of Wnt
signaling
. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal
cell
adhesion and tissue
morphogenesis
and integrity by
regulating
adhesion molecules.
[a.k.a. XM_017009074.1, NP_001351057, CTNND2-213]
12)
Homo sapiens
CEMIP2 -
Cell
surface hyaluronidase;
Cell
surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate- size hyaluronan of approximately 5 kDa fragments. Acts as a
regulator
of angiogenesis and heart
morphogenesis
by mediating degradation of extracellular hyaluronan, thereby
regulating
VEGF
signaling
(By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate.
[a.k.a. A6H8W9, ENSP00000437750, ENST00000396272]
13)
Homo sapiens
UBR4 - E3 ubiquitin-protein ligase UBR4; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane
morphogenesis
and cytoskeletal organization.
Regulates
integrin- mediated
signaling
. May play a role in activation of FAK in response to
cell
-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degrad [...]
[a.k.a. RBAF600, XP_016856319, Q5TBN8]
14)
Homo sapiens
ARHGEF28 - Rho guanine nucleotide exchange factor 28; Functions as a RHOA-specific guanine nucleotide exchange factor
regulating
signaling
pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic
morphogenesis
. Functions also in focal adhesion formation,
cell
motility and B-lymphocytes activation. May
regulate
NEFL expression and aggregation and play a role in apoptosis (By similarity).
[a.k.a. ENST00000513042.6, ENST00000424972, uc010izf.4]
15)
Homo sapiens
LEF1 - Lymphoid enhancer-binding factor 1; Participates in the Wnt
signaling
pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair
cell
differentiation and follicle
morphogenesis
. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1.
Regulates
T-
cell
receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt
signaling
. Isoform 5 [...]
[a.k.a. ENST00000509428, R-HSA-162582, R-HSA-195253]
16)
Homo sapiens
GREM2 - Gremlin-2; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates
signaling
by BMP family members. Contributes to the
regulation
of embryonic
morphogenesis
via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa
cells
.
[a.k.a. XM_011544249.2, R-HSA-162582, CCDS31070]
17)
Homo sapiens
MET - Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces
signals
from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.
Regulates
many physiological processes including proliferation, scattering,
morphogenesis
and survival. Ligand binding at the
cell
surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream
signaling
molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
[a.k.a. 5HTI, R-HSA-6807004, 5DG5]
18)
Mus musculus
Scrib - Protein scribble homolog; Scaffold protein involved in different aspects of polarized
cells
differentiation
regulating
epithelial and neuronal
morphogenesis
. Most probably functions in the establishment of apico-basal
cell
polarity. May function in
cell
proliferation
regulating
progression from G1 to S phase and as a positive
regulator
of apoptosis for instance during acinar
morphogenesis
of the mammary epithelium. May also function in
cell
migration and adhesion and hence
regulate
cell
invasion through MAPK
signaling
. May play a role in exocytosis and in the targeting synaptic vesicle [...]
[a.k.a. XP_017171843, XM_017316354, BAC65493.1]
19)
Mus musculus
Pak3 - Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different
signaling
pathways including cytoskeleton
regulation
,
cell
migration, or
cell
cycle
regulation
. Plays a role in dendrite spine
morphogenesis
as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...]
[a.k.a. R-MMU-1280218, Serine/threonine-protein kinase PAK 3, ENSMUSP00000118549]
20)
Mus musculus
Rasip1 - Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific
regulator
of GTPase
signaling
,
cell
architecture, and adhesion, which is essential for endothelial
cell
morphogenesis
and blood vessel tubulogenesis.
Regulates
the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA
signaling
and dampening ROCK and MYH9 activities in endothelial
cells
. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated trans [...]
[a.k.a. ENSMUST00000057927, ENSMUSG00000044562, E9QLI7]
1034 matches
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